Vitamin D: Boosting Immunity and Fighting Infections

Recently, scientists delved into the immunomodulatory and antiviral properties of vitamin D and its impact on pediatric respiratory health, including COVID-19. This review sheds light on the potential benefits of vitamin D supplementation in children with respiratory tract infections and the ongoing pandemic. Read on to discover the latest findings and insights


Acute respiratory tract infections (ARTI) are prevalent among children, accounting for a significant percentage of pediatric fatalities. This review focuses on upper respiratory tract infections (URTIs) and lower respiratory tract infections (LRTIs), including viral infections caused by various pathogens. Notably, the ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has posed significant challenges in managing pediatric respiratory health.

Vitamin D and Immune Function

Vitamin D plays a crucial role in immune function. It enhances innate immunity, regulates T lymphocyte production, and influences cytokine levels. The vitamin’s role in reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines makes it a potential candidate for combating respiratory infections.

Study Design

The study reviewed relevant articles from PubMed, including clinical trials, systematic reviews, and meta-analyses, focusing on children under 19 years of age. A total of 27 studies met the inclusion criteria, yielding valuable insights into the impact of vitamin D on pediatric respiratory health.

Key Findings

The major circulating form of vitamin D, 25-hydroxycholecalciferol (25(OH)D), exhibits antiviral properties through antimicrobial peptides. Vitamin D receptor (VDR) and CYP27B1, a critical enzyme for vitamin D metabolism, are found in significant quantities in cells and tissues.

Numerous studies indicated a strong association between vitamin D status and the incidence of ARTIs, including COVID-19 infections. Vitamin D deficiency (VDD) was inversely related to the severity of COVID-19 in most cases.

Vitamin D supplementation was found to lower the risk of recurring pneumonia, demonstrating its potential as a preventive measure. The study also highlighted VD’s ability to enhance natural antibodies synthesis, improve immunity, and promote phagocytic activity.

Challenges and Further Research

While systematic reviews have indicated that lower levels of 25(OH)D increase the risk of ARTIs in children, some experimental findings have presented contradictions. The causality between vitamin D and COVID-19 remains an area of ongoing research.


Vitamin D holds promise as an immunomodulatory agent with potential antiviral effects against pediatric respiratory tract infections, including COVID-19. Maintaining adequate vitamin D levels may enhance overall health and reduce the risk of severe infections. Further research is essential to fully understand the impact of vitamin D on respiratory health and its potential in fighting COVID-19. Dietary intake and supplements are recommended to ensure optimal vitamin D levels and combat respiratory infections in all age groups.

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